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Computational Microscopy beyond Perfect Lenses

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posted on 2023-06-22, 16:02 authored by Xingyuan Lu, Minh Pham, Elisa Negrini, Damek Davis, Stanley J. Osher, Jianwei Miao
We demonstrate through mathematical analysis and numerical experiments that in situ coherent diffractive imaging (CDI), which harnesses the coherent interference between a strong and a weak beam illuminating a static and dynamic structure, respectively, could be the most dose-efficient imaging method. At low doses, in situ CDI can achieve higher resolution than perfect lenses with the point spread function as a delta function. We also use numerical experiments to show that the combination of in situ CDI and ptychography can reduce the dose by two orders of magnitude over ptychography under some conditions. We expect that computational microscopy based on in situ CDI can be implemented in different imaging modalities with photons and electrons for low-dose imaging of radiation-sensitive materials and biological samples.

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