Experimental insights into data augmentation techniques for deep learning-based multimode fiber imaging: limitations and success

Multimode fiber~(MMF) imaging using deep learning has high potential to produce compact, minimally invasive endoscopic systems. Nevertheless, it relies on large, diverse real-world medical data, whose availability is limited by privacy concerns and practical challenges. Although data augmentation has been extensively studied in various other deep learning tasks, it has not been systematically explored for MMF imaging. This work provides the first in-depth experimental and computational study on the efficacy and limitations of augmentation techniques in this field. We demonstrate that standard image transformations and conditional generative adversarial-based synthetic speckle generation fail to improve, or even deteriorate, reconstruction quality, as they neglect the complex modal interference and dispersion that results in speckle formation. To address this, we introduce a physical data augmentation method in which only organ images are digitally transformed, while their corresponding speckles are experimentally acquired via fiber. This approach preserves the physics of light-fiber interaction and enhances the reconstruction structural similarity index measure~(SSIM) by up to 17\%, forming a viable system for reliable MMF imaging under limited data conditions.