Quantum correlation light-field microscope with extreme depth of field

Light-field microscopy (LFM) is a 3D microscopy technique whereby volumetric information of a sample is gained in a single shot by simultaneously capturing both position and angular information of light emanating from a sample. Conventional LFM designs require a trade-off between position and angular resolution, requiring one to sacrifice resolving power for increased depth of field (DOF) or vice versa. In this work, we demonstrate a LFM design that does not require this trade-off by utilizing the inherent strong correlation between spatial-temporal entangled photon pairs. Here, one photon from the pair is used to illuminate a sample from which the position information of the photon is captured directly by a camera. By virtue of the strong momentum/angular anti-correlation between the two photons, the angular information of the illumination photon can then be inferred by measuring the angle of its entangled partner on a different camera. We demonstrate that a resolving power of 5$\mu$m can be maintained with a DOF of $\sim500$$\mu$m, over an order of magnitude larger compared to conventional LFM designs. In the extreme, at a resolving power of 100$\mu$m, it is possible to achieve near infinite DOF