Ultrasensitive surface plasmon resonance-based biosensor for efficient detection of SARS-CoV-2 Virus in the near-infrared region

This work presents a high-performance, multilayered surface plasmon resonance (SPR)-based sensor designed to enhance performance parameters in the near-infrared (NIR) region through angular interrogation. The multi-layered sensor consists of a bimetallic layer (Aluminum (Al) & Gold (Au)), a dielectric layer (MgF2), and an optimized number of 2D nanomaterial (MoS2) layers. The proposed SPR sensor is numerically designed and analyzed through simulation using the transfer matrix and finite element methods to achieve high sensitivity, figure of merit (FOM), and detection accuracy. The simulated results revealed that the proposed plasmonic sensor (Glass prism/Al/Au/MgF2/MoS2/sensing sample) exhibits a maximum sensitivity of 372°/RIU, FOM of 1690.90 RIU-1, and detection accuracy of 4.54 degree-1. The outcomes from this work indicate that the developed SPR sensor exhibits excellent detection capabilities for refractive index changes, including those caused by the novel coronavirus, making it a promising prospect for biosensing applications.